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This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body’s natural substances (serotonin) that causes vomiting.
Possible side effects of Zofran: All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Constipation; drowsiness; headache; irritation at the site of injection; tiredness.
While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. Serotonin receptors of the 5-HT3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema.
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Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.
Zofran is used in the treatment of nausea/vomiting; gastroenteritis; alcohol dependence; obsessive compulsive disorder; nausea/vomiting, chemotherapy induced (and more), and belongs to the drug class 5HT3 receptor antagonists. … Zofran 8 mg is not a controlled substance under the Controlled Substance Act (CSA).