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Chemical class Examples Mode of actionTetracyclines Tetracycline Inhibit translation (protein synthesis)Semisynthetic tetracycline Doxycycline Inhibit translation (protein synthesis)
Chloramphenicol is a bacteriostatic by inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation.
Chloramphenicol eye drops and eye ointment are used to treat bacterial eye infections. Eye infections are a common cause of conjunctivitis. In conjunctivitis, your eye becomes inflamed, feels gritty, and may water more than usual.
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Chloramphenicol is bactericidal at clinically achievable concentrations against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. It is bacteriostatic against gram-negative bacilli of the family Enterobacteriaceae and against Staphylococcus aureus.
Chloramphenicol Chloramphenicol Inhibits translation (protein synthesis)Quinolones Nalidixic acid Inhibits DNA replication