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    Take spironolactone exactly as your doctor has told you. The usual dose varies from 25 mg to 200 mg. Depending upon which dose is right for you, you may be asked to take several tablets a day but these are generally taken at the same time. Take the tablets with or just after a meal.
    The diuretic spironolactone can cause dangerous hyperkalaemia in patients who are also taking angiotensin converting enzyme (ACE) inhibitors, another drug that, like spironolactone, is used to treat congestive heart failure.
    Time to peak plasma concentration is approximately one hour. Distribution � Although the plasma half life of spironolactone itself is short (1.3 hours) the half lives of the active metabolites are longer (ranging from 2.8 to 11.2 hours). Spironolactone is estimated to be 90% protein bound.
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    No, Spironolactone is an aldosterone blocking agent blocking the effects of the adrenal hormone Aldosterone that is part of the renin angiotensin system, inducing water and salt retention, thus causing water overload and maybe high blood pressure
    High-potassium fruits you should avoid when taking Aldactone include papaya, cantaloupe, prune juice, honeydew melons, bananas, raisins, mangoes, kiwis, oranges and orange juice. High-potassium vegetables to avoid include tomatoes, tomato juice, white and sweet potatoes, asparagus, pumpkin and Brussels sprouts

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