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How is this medicine (Sinemet) best taken? Use Sinemet (carbidopa and levodopa tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take with or without food. If you take an iron product or a multivitamin that has iron, ask your doctor or pharmacist how to take it with this medicine. Iron may lower how well your body is able to absorb Sinemet.
Unfortunately, it can cause side effects, like nausea, vomiting, sleepiness, and low blood pressure. If you take levodopa over a long period of time, you may experience involuntary twisting or writhing movements (dyskinesia), and possibly psychotic delusions or hallucinations
What do I need to tell my doctor BEFORE I take Sinemet? If you have an allergy to levodopa, carbidopa, or any other part of Sinemet (carbidopa and levodopa tablets). If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have any of these health problems: Glaucoma, a skin lump or growth, or a history of skin cancer.
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Call your doctor at once if you have any of these serious side effects: restless muscle movements in your eyes, tongue, jaw, or neck; worsening of tremors (uncontrolled shaking); high fever, stiff muscles, sweating, fast or uneven heartbeats, rapid breathing, feeling like you might pass out; seizure (convulsions); painful or difficult urination; severe nausea, vomiting, or diarrhea; uneven heart rate or fluttering in your chest; confusion, hallucinations, anxiety, agitation, depressed mood, thoughts of suicide or hurting yourself; chest pain or heavy feeling, pain spreading to the arm or shoulder.
The active ingredient in Generic Sinemet, Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Activation of central dopamine receptors improves the symptoms of Parkinson’s disease.

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