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How should I take Coumadin? Take Coumadin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take Coumadin in larger or smaller amounts or for longer than your doctor tells you to.
The duration of anticoagulant therapy for a first-time deep venous thrombosis is usually 3 to 12 months, depending on the reversibility of the condition which may have predisposed this patient to thrombosis. For patients with a first episode of DVT secondary to a reversible risk factor, 3 months of warfarin therapy is recommended. For patients with a first episode of idiopathic DVT, at least 6 to 12 months of treatment is recommended. For patients with two or more episodes of documented DVT, indefinite treatment with warfarin is recommended. For patients with a first episode of DVT who have documented antiphospholipid antibodies or who have two or more thrombophilic conditions, treatment for 12 months is recommended and indefinite therapy is suggested. For patients with a first episode of DVT who have documented deficiency of Protein C or Protein S, deficiency of antithrombin, or the Factor V Leiden or prothrombin 20210 gene mutation, homocystinemia, or high Factor VIII levels, treatment for 6 to 12 months is recommended and indefinite therapy is suggested for idiopathic thrombosis.
It is not known whether warfarin passes into breast milk. Tell your doctor if you are breast-feeding a baby. Watch for signs of bruising or bleeding in the baby if you take Coumadin while you are nursing.
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You should not take Coumadin if you cannot be reliable in using it because of alcoholism, psychiatric problems, dementia, or similar conditions. Coumadin can make you bleed more easily, especially if you have: a history of bleeding problems; high blood pressure or severe heart disease; kidney or liver disease; cancer; a disease affecting the blood vessels in your brain; a history of stomach or intestinal bleeding; a surgery or medical emergency, or if ou receive any type of injection (shot); if you are 65 or older; or if you are severely ill or debilitated.
Ask your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes acetaminophen (Tylenol), aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. These medicines may affect blood clotting and may also increase your risk of stomach bleeding.

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